Elan Drug Technologies

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PRODAS® Multiparticulate Minitab

 

Programmable Oral Drug Absorption System (PRODAS^® Technology) is a multiparticulate technology, which is unique in that it combines the benefits of tabletting technology within a capsule.

Benefits offered by the PRODAS^® technology include:

• multi-unit system, which allows customised release and absorption patterns
• equivalent bioavailability to reference multiple dose product in a once daily formulation
• minimum peak to trough ratio at steady state
• minimal food impact
• pulsed / programmed release to different sites in the GI tract
• combines tabletting technology with multi-unit features
• tablet efficiency
• process control
• functional coating(s)

The PRODAS^® delivery system is presented as a number of minitablets combined in a hard gelatin capsule. Very flexible, the PRODAS^® technology can be used to target the profile of a candidate drug. It is possible to incorporate different minitablets, each one formulated individually and designed to release drug at different sites so that higher dose loading is possible within the gastrointestinal tract. It is also possible to incorporate minitablets of different sizes so that high drug loading is possible.


PRODAS^® technology, by incorporating minitablets with different release rates, can display the characteristics of a number of different conventional dosage forms:

• immediate release component to mimic the onset of a conventional tablet form ensuring that the once daily formulation is as fast acting
• delayed release component for site/regional release and/or food resistance
• sustained release component for additional controlled release/profile extension

The data above shows the smooth plasma profile achieved using the PRODAS^® technology compared to four hour dosing by conventional means.